1. Tamoxifen retinopathy: a case report - PMC - NCBI
Sep 17, 2015 · It had been reported that paclitaxel could cause macular edema and transient blurred vision with photopia while epirubicin mainly affected the ...
To present a case of tamoxifen retinopathy on a 57-year-old woman.An observational case.A review of history, clinical examination, and findings on Spectral-domain Optical Coherence Tomography (SD-OCT), fluorescein angiogram (FA) and electro-oculogram ...
2. Should we discontinue tamoxifen in a patient with vision-threatening ...
Mar 14, 2003 · The common toxic effects included inner retinal crystalline deposition, macular oedema, whorl-like corneal opacities, posterior subcapsular lens ...
Eye - Should we discontinue tamoxifen in a patient with vision-threatening ocular toxicity related to low-dose tamoxifen therapy?
3. Unilateral Tamoxifen-Induced Retinopathy as a Consequence of ...
Ophthalmic complications of tamoxifen therapy are relatively rare [7]. The range of ocular toxicity is between 0.9% and 12.0% and increases in higher drug doses ...
Tamoxifen is a drug used in breast cancer therapy, which inhibits the division of neoplastic cells targeting estrogen receptors. The drug is generally well-tolerated and its use does not cause serious side-effects. The standard dose of the drug is 20 mg once a day for 3 to 5 years. Available epidemiological data have shown that the incidence of ocular toxicity of tamoxifen ranges between 0.9% and 12.0% and increases with higher tamoxifen dose. A rare known complication of tamoxifen use is the development of retinopathy. We present a case of 57-year-old woman presented to an ophthalmologist with decreased visual acuity in her right eye. She has been treated with tamoxifen 20 mg daily for 7 years for breast cancer. Clinical examination and multimodal imaging methods help confirm the diagnosis of unilateral tamoxifen associated retinopathy (TAR). Optical coherence tomography angiography (OCTA) was crucial in the diagnostic process and differential diagnosis, especially in differentiating it from type 2 macular telangiectasias. The correct diagnosis of TAR is very important in deciding the treatment option of tamoxifen. Based on our diagnosis, the oncologist recommended another course of treatment. Tamoxifen therapy was discontinued and switched to letrozole 2.5 mg once a day. The patient attends ophthalmological examination regularly. Visual acuity, OCT and OCTA results remain stable.
4. Ocular toxicity in low-dose tamoxifen: a prospective study - Nature
The aim of our study was to look prospectively at the incidence, symptomatology, course and reversibility of low-dose tamoxifen ocular toxicity in 65 patients.
5. Vision and Eye Problems - Breastcancer.org
Sep 1, 2023 · Though uncommon, breast cancer treatment may affect your eyes and vision, including causing red, itchy, or dry eyes; watery eyes; blurry or ...
Though uncommon, breast cancer treatment may affect your eyes and vision, including causing red, itchy, or dry eyes; watery eyes; blurry or double vision; or making you see dark spots.
6. Mar-2019 - West Coast Retina
Other features of tamoxifen retinal toxicity include decreased visual acuity, decreased color vision, and macular edema. Patients have also been reported to ...
Case of the Month
7. Breast Cancer Treatment and Protecting the Eye
Oct 1, 2020 · According to the American Academy of Ophthalmology, some research has indicated that long-term use of tamoxifen can lead to eye issues, such as ...
Breast cancer is treatable, often with a combination of medication and surgery. Although treatment is needed, it can have side effects, including those that may affect the eyes. Keep reading below to learn more about how breast cancer treatment can affect
8. A Case of Tamoxifen Keratopathy | Cornea | JAMA Ophthalmology
Toxic reactions to tamoxifen, such as decreased visual acuity, bilateral macular edema, and yellow-white dots in the paramacular and foveal areas, are ...
Tamoxifen citrate (ICI46474) is an antiestrogenic agent1 used in cases of disseminated breast carcinomas and as adjuvant postoperative therapy. Toxic reactions to tamoxifen, such as decreased visual acuity, bilateral macular edema, and yellow-white dots in the paramacular and foveal areas, are...
9. Tamoxifen : Side Effects of Medications : The Eyes Have It
How does it appear? · Perifoveal white crystalline deposits · Blurred vision · Cystoid macular edema ...
10. [PDF] Tamoxifen-associated eye disease. A review. - eScholarship
The first cases of ocular toxicity due to tamoxifen were reported by Kaiser-Kupfer and Lippman2 in 1978 among women receiving extremely high-dose tamoxifen (120 ...